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What is the Best Vitamin B12 ? Our Advice and Reviews (2023)

Do you feel weak and tired for no particular reason?  

It is quite possible that you are deficient in vitamin B12, also known as the energy vitamin, because of its fundamental energetic power for the functioning of the body.  

Vitamin B12 also contributes to a healthy cardiovascular system, supports the nervous system and promotes the production of neurotransmitters.  

Today the market is full of food supplements that seem to be all alike, but whose quality and effectiveness is very variable ... That's why it is important to be well informed to choose the best vitamin B12.  

If you have decided to supplement with vitamin B12 and are wondering what the best source of vitamin B12 is or what vitamin B12 to buy, our article will answer all your questions!

best vitamin B12

A quick reminder: what is vitamin B12?

Vitamin B12 is the most important and most complex vitamin of the B group, as well as the last one to be discovered in 1948. For the record, it is the only natural substance to contain a metallic element.  

We are talking about cobalt, one of the rarest elements, which gives vitamin B12 its chemical name, cobalamin.   

The original source of vitamin B12 is that produced by bacteria, which is absorbed by the body through foods of animal origin.   

For more information, read our article on the best food sources of vitamin B12, as well as this PubMed article on the bioavailability of vitamin B12 sources.   

Vitamin B12 will be your ally in case of fatigue, tingling in the hands and feet, headaches, mood swings, anemia or suspected malabsorption disorders.   

Are you concerned about vitamin B12 deficiency?  

To decide, the article The 6 signs of a Vitamin B12 deficiency will help you have a clearer idea. And don't forget our complete guide on vitamin B12, which details all the properties of this fabulous vitamin!   

But let's get back to our basic question: how do you choose the best vitamin B12?

What are the selection criteria?

And more concretely, which vitamin B12 to buy among the plethora of offers existing on the market? 

Let's look at the three main selection criteria.

The shape

A first criterion for choosing the best source of vitamin B12 is its form

Indeed, although it is known as vitamin B12, this B vitamin exists in four very similar chemical forms, three of natural origin and one synthetic:

  • Methylcobalamin;
  • Adenosylcobalamin;
  • Hydroxocobalamin;
  • Cyanocobalamin.

Vitamin B12 content

Often, the attractive price of a food supplement hides a dosage so low in active principle, that one is obliged to swallow many capsules or tablets to reach the optimal dosage.   

However, it is important to know that in the case of vitamin B12, the limited absorption capacity of the body implies the need to provide much more than the recommended daily dose.  

This is why, in order to ensure the 4 µg/d that ANSES recommends for adults aged 18 and over, it is advisable to opt for a dosage between 500 and 1000 µg.  

This is confirmed by a study conducted by the Dutch University of Wageningen, which found that a slight vitamin B12 deficiency in the elderly needs to be compensated for by a dosage of 500 µg to 1000 µg to ensure effective supplementation.  

This is good news: our vitamin B12 is highly dosed at 1,000 µg and you only need to take one capsule a day to cover your needs for four months! Practical, isn't it? 

We recommend

best vitamin B12

Vitamin B12

Vitamin B12 in its active and bioavailable form, methylcobalamin.

  • ✅ 100% pure methylcobalamin
  • ✅ Optimal dosage 1000 μg
  • ✅ 4 months of treatment
  • ✅ Made in France
See the product

The composition

If, like us, you attach importance to the composition of your food supplements, you have a preference for the purest possible products, containing few additives.  

And this is the case with our vitamin B12, guaranteed without addictives or colorants!

What is the best vitamin B12?

best vitamin B12

Traditionally, the best-known and most widely used way to supplement with vitamin B12 was by intramuscular route and the chemical form chosen was the synthetic vitamin B12, cyanocobalamin.  

On this subject, the less young among us will probably keep the unpleasant memory of B12 injections, administered in case of anemia!  

To dispel preconceived notions, a study of vitamin B12-deficient children in Turkey concluded that " sublingual methylcobalamin treatment, which is a new method of treatment, has been shown to be as effective as oral and intramuscular cyanocobalamin treatments.  

But how do you distinguish between these four forms of vitamin B12?  

In short, methylcobalaminand adenosylcobalamin are two naturally occurring coenzymes found in foods. They act synergistically in slightly different ways to cover most of our vitamin B12 needs. Hydroxocobalamin is a highly bioavailable form of vitamin B12, used to treat people with severe deficiencies. Finally, cyanocobalamin is a synthetic form of vitamin B12, which the body converts into adenosylcobalamin and methylcobalamin before it can be used.   

Let's take a closer look at the four types of vitamin B12, with their advantages and disadvantages. 

Natural vitamin B12

Natural vitamin B12 comes in three types: methylcobalamin, adenosylcobalamin and hydroxocobalamin. 


Methylcobalamin is found naturally in foods of animal origin such as meat, fish, milk and eggs.  

It is the most active form of vitamin B12, used primarily in the liver, brain and nervous system. There's a reason we chose it to make our Vitamin B12!

Benefits: it's the most bioavailable type of vitamin B12, which means it's more easily absorbed by the body.    

⛔ D isadvantages: it can be a bit more expensive compared to the synthetic form, cyanocobalamin, for obvious manufacturing cost reasons.   

 👨‍👩‍👧‍👦 For whom: for all, especially to compensate for anemia or vitamin B12 deficiency. It can also be recommended for chronic smokers and for patients suffering from liver or kidney failure.


Adenosylcobalamin is also a natural coenzyme form of vitamin B12. We can consider it an ally of methylcobalamin, as they work in synergy to provide our body with nearly 100% optimal coverage.  

Adenosylcobalamin is particularly important for supporting and protecting the mitochondria in our cells. These are like power plants in every cell and adenosylcobalamin helps them burn food efficiently to produce energy and boost metabolism.  

In addition, adenosylcobalamin is a key component of the myelin sheath that protects nerve cells, allowing them to react very quickly to stimuli.   

Benefits: adenosylcobalamin plays many vital roles in the body, including carbohydrate, fat and protein metabolism. Without this form of vitamin B12, the burning of these food substances becomes inefficient and causes fatigue, pain, increased lactic acid and other metabolic disorders.   

⛔ D isadvantages: as with methylcobalamin, the price is a bit higher compared to the synthetic form.   

👨‍👩‍👧‍👦 For whom: for all, in particular for all those who are concerned by neurological or cognitive disorders, thanks to its role in the good transmission of the nervous signals.  


Hydroxocobalamin is naturally produced by bacteria in the digestive tract during the breakdown of food sources. It can also be produced in the laboratory by extracting it from microorganisms.  

This form of vitamin B12 is easily converted by the body into adenosylcobalamin and methylcobalamin, allowing the cells to absorb and use it.  

Benefits: hydroxycobalamin is stored longer in the bodyand then excreted slowly by the kidneys. Because of this, it is often used in intramuscular injections of vitamin B12.   

Cons: Let's be honest, who among us likes shots? Generally, oral intake is more appreciated and is more convenient for most people!   

👨‍👩‍👧‍👦 For whom: hydroxocobalamin is particularly useful in the treatment of vitamin B12 deficiency secondary to disorders that alter its absorption by the gastrointestinal tract, including malabsorption and pernicious anemia. In addition, it is very effective in detoxification in cases of hydrocyanic acid poisoning. 

The synthetic vitamin B12, cyanocobalamin

Let's finish our overview with cyanocobalamin. 

It is an artificial form of vitamin B12, which the body converts into the active forms of methylcobalamin and adenosylcobalamin, ready to be used.

Manufactured by humans, this form of vitamin B12 is not found in its natural state in food sources: it can only be found in food supplements.  

Cyanocobalamin B12 contains a cyanide molecule that makes it stable in products and in the body. Cyanide is toxic, but in the infinitesimal amounts found in cyanocobalamin, it is safe to take.     

Advantages: the synthetic form is also the cheapest and very easy to find, not only in dietary supplements, but even added to everyday food products.    

⛔ D isadvantages: cyanide, in small amounts be it, is not really beneficial to our body, so what need is there to introduce it into the body if we have safer alternatives?    

👨‍👩‍👧‍👦 For whom: if you are on a very tight budget and, despite this, you do not want to give up your vitamin B12 supplementation. 

best vitamin B12

Vitamin B12 in capsules, gummies, powder or drops: which form to choose?

To fill up on vitamin B12, you have plenty of choices!  

From classic forms such as capsules, through drops to gummies, each form has its advantages and disadvantages.  

We advise you to choose the one that suits you best and that corresponds to your tastes, your lifestyle and your nutritional needs. For example, if you have difficulty swallowing capsules, drops or gummies (jelly beans) will suit you better.  

Drops have the advantage of being easily mixed with food.  

Gummies will particularly please the youngest and the greediest, but they have some disadvantages. Indeed, they generally contain added sugars or coloring agents, are weaker than the other forms and their attractive aspect can push us to an overconsumption.

That's why at Novoma we have chosen vitamin B12 in capsules: they are tasteless and very practical, because you can swallow them with a little liquid anywhere and anytime.

So what is the best vitamin B12?

For the final word on the question of which vitamin B12 to buy, know that the choice is usually between methylcobalamin or cyanocobalamin. That is, between a natural form and a synthetic form.  

Although the body absorbs cyanocobalamin very well, methylcobalamin is considered to be better retained and longer lasting among the different types of vitamin B12.  

This is why we have a preference for this form of vitamin B12, which is natural and safe.  

Made in France, our vitamin B12 contains 120 capsules, which have the considerable advantage of being highly dosed and guarantee you a quality vitamin B12 intake for 4 months. Of what to recover the physical and mental form and to make the full one of energy!

We recommend

best vitamin B12

Vitamin B12

Vitamin B12 in its active and bioavailable form, methylcobalamin.

  • ✅ 100% pure methylcobalamin
  • ✅ Optimal dosage 1000 μg
  • ✅ 4 months of treatment
  • ✅ Made in France
See the product


Co-founder of NOVOMA

Passionate and expert in micro-nutrition, Lucas founded Novoma in 2012. It is with conviction that he develops food supplements with effective active ingredients, carefully chosen and 100% clean, to best meet the needs of the body.

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